Which group of medications for depression is usually recommended to be taken at bedtime?

Tricyclic Antidepressants (TCAs) are often recommended to be taken at bedtime due to their sedative effects, which can help patients who struggle with insomnia as a symptom of their depression. These medications can cause drowsiness, making them more suitable for nighttime use to improve sleep quality while also managing depressive symptoms.

The side effects of TCAs include sedation, which can be beneficial for individuals who experience sleep disturbances related to their depression. By taking these medications in the evening, patients can maximize their therapeutic effects while minimizing daytime drowsiness, thus enhancing their overall functioning during the day.

In contrast, other classes of antidepressants, such as SSRIs and MAOIs, are usually recommended for daytime use as they tend to be more activating rather than sedating. Atypical antidepressants vary in their sedative effects, with some having the potential to be taken at night, but TCAs are more universally recognized for this specific recommendation.