Which type of antidepressants is known for having the fewest side effects?

Selective Serotonin Reuptake Inhibitors (SSRIs) are recognized for having a more favorable side effect profile compared to other classes of antidepressants. They primarily work by increasing the levels of serotonin in the brain, which is often linked to regulating mood. This mechanism tends to result in fewer and less severe side effects than those associated with tricyclic antidepressants and monoamine oxidase inhibitors.

Tricyclic antidepressants, while effective, can cause a range of side effects such as weight gain, dry mouth, constipation, and dizziness, due to their broad action on various neurotransmitters and receptors. Similarly, monoamine oxidase inhibitors can lead to significant dietary restrictions and potential hypertensive crises when certain foods or medications are combined, limiting their usage.

Norepinephrine-Dopamine Reuptake Inhibitors also have their own set of side effects, although they differ from SSRIs. These may include increased anxiety or agitation in some individuals.

The favorable profile of SSRIs makes them a first-line treatment for depression and anxiety disorders, making them a preferred choice among healthcare providers when considering patient tolerance and adherence to treatment.